Milk Thistle Silybum marianum

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What is Milk Thistle Silybum marianum

Milk Thistle Silybum marianum also known as Carduus marianum or milk thistle, is an herb that yields a crude mixture of hepatoprotective principles designated as silymarin. While silymarin is found in the entire plant, but the highest concentration (4—6%) is found within the ripe seeds (fruit).

Silymarin consists of several flavonoligans: silibinin, silydianin, silychristin, and others. Silibinin (also known as silybin) is the most pharmacologically active flavonoligan of silymarin, and the measured content of silibinin is used to standardize milk thistle products.

In addition to flavonoligands, the milk thistle fruits also express betaine and linoleic acid.

Silybum marianum, also known as Carduus marianum or milk thistle, is an herb that yields a crude mixture of hepatoprotective principles designated as silymarin.

While silymarin is found in the entire plant, but the highest concentration (4—6%) is found within the ripe seeds (fruit).

Silymarin consists of several flavonoligans: silibinin, silydianin, silychristin, and others. Silibinin (also known as silybin) is the most pharmacologically active flavonoligan of silymarin, and the measured content of silibinin is used to standardize milk thistle products. In addition to flavonoligands, the milk thistle fruits also express betaine and linoleic acid.

Silybum marianum, also known as Carduus marianum or milk thistle, is an herb that yields a crude mixture of hepatoprotective principles designated as silymarin. While silymarin is found in the entire plant, but the highest concentration (4—6%) is found within the ripe seeds (fruit).

Silymarin consists of several flavonoligans: silibinin, silydianin, silychristin, and others. Silibinin (also known as silybin) is the most pharmacologically active flavonoligan of silymarin, and the measured content of silibinin is used to standardize milk thistle products.

In addition to flavonoligands, the milk thistle fruits also express betaine and linoleic acid.

Indications

  1. dyspepsia
  2. hepatic cirrhosis
  3. hepatitis A infection
  4. hepatitis B infection
  5. hepatitis C infection
  6. mushroom poisoning
  7. nutritional supplementation

For the relief of occasional, non-ulcer dyspepsia

Side Effects

  1. abdominal pain
  2. arthralgia
  3. contact dermatitis
  4. diaphoresis
  5. diarrhea
  6. headache
  7. nausea
  8. pruritus
  9. rash
  10. thrombocytopenia
  11. urticaria
  12. vomiting
  13. weakness

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • alcoholism
  • atopy
  • breast-feeding
  • children
  • infants
  • jaundice
  • pregnancy
  • renal disease
  • renal impairment

Interactions

  • Ethanol
  • Simeprevir

Ethanol: (Moderate) Concurrent use of ethanol-containing beverages and milk thistle, Silybum marianum is not recommended; the effects of ethanol on the liver may antagonize the hepatocytoprotective actions of milk thistle. 

(Moderate) Excessive ethanol (e.g., alcoholism) may result in increased urinary excretion of magnesium. Avoid high intakes of ethanol while taking magnesium salts. 

Simeprevir: (Major) Avoid concurrent use of simeprevir and milk thistle, Silybum marianum. Inhibition of CYP3A4 by milk thistle may increase the plasma concentrations of simeprevir, resulting in adverse effects.

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