Lemierre syndrome

Lemierre syndrome

Lemierre syndrome is one of the rare diseases

This is an infectious disease affecting the oropharyngeal area

Most common in young adults and immunocompetent adolescents

Most potentially a lethal condition


How common is Lemierre syndrome

Approximately affects 0.6-2.1 per million

The incidence of Lemierre syndrome has significantly dropped after the advent of antibiotics.

Males are affected than females

Almost more than 65% of patients fall between the range of 16-26 years.

Synonyms of Lemierre syndrome

  • Lemierre postanginal sepsis
  • Postanginal sepsis secondary to orophyngeal infection
  • Septic phlebitis of the internal jugular vein
  • Postanginal septicemia

What causes Lemierre syndrome

Causative agent is Fusobacterium necrophorum

Features of Lemierre syndrome

This condition is characterized by septic thrombophlebitis of the internal jugular vein

This thrombophlebitis leads to septic, usually pulmonary, embolism, associated with ENT (ear, nose, and throat) infection

Symptoms of Lemierre syndrome

This condition usually manifests with the below symptoms

  • Fever
  • Neck pain and swelling
  • Trismus
  • Tonsillopharyngitis
  • Pain behind the angle of jaw

This condition affects almost all the organs but the most commonly infected organs are the lungs

Diagnostic arthrocentesis may be required in around 14% to 30% probably because of symptoms of septic arthritis

Bacteremia and distal infective thromboembolism are common

Complications of Lemierre syndrome

Meningitis has also been shown to complicate up to 3% of cases


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