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Feingold syndrome
This is a rare genetic condition
A congenital malformation syndrome
Features of Feingold syndrome
This disease is characterized by the below features
- Mild learning deficits
- short stature
- Short palpebral fissures
- microcephaly
- numerous digital anomalies like brachymesophanlangy, fifth finger clinodactyly, syndactyly of toes and hypoplastic thumbs
How common is Feingold syndrome
<1 / 1000000
Synonyms of Feingold syndrome
- Brunner-Winter syndrome
- Digital anomalies with short palpebral fissures and atresia of esophagus or duodenum
- FGLDS
- FS
- MMT
- MODED syndrome
- Microcephaly-digital anomalies-normal intelligence syndrome
- Microcephaly-intellectual disability-tracheoesophageal fistula syndrome
- Microcephaly-oculo-digito-esophageal-duodenal syndrome syndrome
- ODED syndrome
- Oculo-digito-esophageal-duodenal syndrome
Inheritance Pattern
Autosomal dominant
In what age is Feingold syndrome typical onset
Neonatal
Symptoms of Feingold syndrome
Very frequent Symptoms
- Brachydactyly
- Clinodactyly of the 5th finger
- Deviation of the 2nd finger
- Microcephaly
- Short palpebral fissure
Frequent Symptoms
- Anteverted nares
- Depressed nasal bridge
- External ear malformation
- Hallux valgus
- Intellectual disability
- Micrognathia
- Short stature
- Toe syndactyly
Occasional Symptoms
- Abnormal form of the vertebral bodies
- Abnormality of the spleen
- Annular pancreas
- Duodenal atresia
- Esophageal atresia
- Oral cleft
- Patent ductus arteriosus
- Sensorineural hearing impairment
What causes Feingold syndrome
The gene for Feingold syndrome maps to 2p23-p24.
But this gene yet to be identified.
