Feingold syndrome

Feingold syndrome

This is a rare genetic condition

A congenital malformation syndrome

Features of Feingold syndrome

This disease is characterized by the below features

  • Mild learning deficits
  • short stature
  • Short palpebral fissures
  • microcephaly
  • numerous digital anomalies like brachymesophanlangy, fifth finger clinodactyly, syndactyly of toes and hypoplastic thumbs

How common is Feingold syndrome

<1 / 1000000

Synonyms of Feingold syndrome

  • Brunner-Winter syndrome
  • Digital anomalies with short palpebral fissures and atresia of esophagus or duodenum
  • FS
  • MMT
  • MODED syndrome
  • Microcephaly-digital anomalies-normal intelligence syndrome
  • Microcephaly-intellectual disability-tracheoesophageal fistula syndrome
  • Microcephaly-oculo-digito-esophageal-duodenal syndrome syndrome
  • ODED syndrome
  • Oculo-digito-esophageal-duodenal syndrome

Inheritance Pattern

Autosomal dominant 

In what age is Feingold syndrome typical onset


Symptoms of Feingold syndrome

Very frequent Symptoms

  • Brachydactyly 
  • Clinodactyly of the 5th finger 
  • Deviation of the 2nd finger 
  • Microcephaly 
  • Short palpebral fissure 

Frequent Symptoms

  • Anteverted nares 
  • Depressed nasal bridge
  • External ear malformation 
  • Hallux valgus 
  • Intellectual disability 
  • Micrognathia 
  • Short stature 
  • Toe syndactyly 

Occasional Symptoms

  • Abnormal form of the vertebral bodies
  • Abnormality of the spleen 
  • Annular pancreas 
  • Duodenal atresia 
  • Esophageal atresia 
  • Oral cleft
  • Patent ductus arteriosus
  • Sensorineural hearing impairment 

What causes Feingold syndrome

The gene for Feingold syndrome maps to 2p23-p24.

But this gene yet to be identified.


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