Significance of an elevated maternal serum AFP level

What is the significance of an elevated maternal serum AFP level?

An elevated maternal serum AFP level may prompt an amniocentesis because an elevated level in the amniotic fluid is strong evidence of a fetal anomaly, usually a neural tube or abdominal wall defect. Maternal serum AFP is usually high in multiple gestations and is normally higher than the overall population average in some ethnic groups.

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