Pathophysiology of mood disorders

What is the basic pathophysiology of mood disorders? 

Mood disorders are heterogeneous clinically, a variety of pathoetiologies are possible, and the specific pathophysiology is not well understood.

Most models of depression involve catecholamine (serotonin, dopamine, and norepinephrine) imbalances and involve dysfunctional medial frontal–subcortical networks.

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