Why is hyperoxaluria important in nephrolithiasis?
Oxalate is a significant component of the most commonly formed stones (calcium oxalate) and contributes to urine supersaturation. Previously, it was believed to be a much stronger stimulus to calcium oxalate stone formation compared with calcium. Newer data suggest that calcium may be just as potent; however, a high urinary concentration of either calcium or oxalate is a potent stimulus for calcium oxalate stone formation.
