Which other autoantibodies other than ANA and ANA profile can be helpful in the diagnosis of systemic juvenile CTD?
Antibodies reactive with Scl-70 are not typically measured in the standard ANA profile but are found in 15% to 20% of individuals with SSc. Myositis-associated and myositis-specific antibodies are found in distinct subsets of children with JDM. If present, their clinical associations are sometimes similar to adults, such as anti-Jo-1 identifying those children at increased risk for developing interstitial lung disease. Vasculitic syndromes associated with the presence of antineutrophil cytoplasmic antibodies (ANCA, cytoplasmic or perinuclear) are granulomatosis polyangiitis (GPA, formerly Wegener), microscopic polyangiitis (MPA), eosinophilic granulomatosis (aka Churg–Strauss syndrome), and crescentic glomerulonephritis. Rheumatoid factor (RF) is frequently positive in Sjögren syndrome and MCTD.
