Which enzymes are important in collagen degradation

Which enzymes are important in collagen degradation? How are they regulated?

The most important collagenolytic enzymes responsible for the cleavage of type I collagen belong to the matrix metalloproteinase (MMP) group. The collagenases are secreted in latent form and, when activated, cleave the collagen molecule at a single specific site following a glycine residue located about three quarters of the distance from the amino terminal end (between residues 775 and 776 of the α1[I] chain). Gelatinases and stromelysins then degrade the unfolded fragments.

Both α-macroglobulin and tissue inhibitors of metalloproteases (1 to 4) are capable of inhibiting collagenase activity. It is likely that other collagen types have type-specific collagenases capable of degrading them. Serum procollagen peptides, urinary hydroxyproline, urinary pyridinoline/deoxypyridinoline crosslinks, and serum C -telopeptides and urinary N -telopeptides are used as measures of collagen turnover.


Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

Scroll to Top