What structural changes occur in the kidney with age

What structural changes occur in the kidney with age?

A progressive decrease in kidney weight and size occurs with increasing age as the glomeruli and the interstitium undergo fibrosis and sclerosis, tubules atrophy with drop in number and size, and vasculature scleroses and simplifies.

Individual rates of kidney senescence may vary as various factors that are known to mediate fibrosis such as angiotensin II, transforming growth factor, nitric oxide, advanced glycosylated end products, oxidative stress, and factors associated with reducing sclerosis such as Klotho (antiaging transmembrane protein) and autophagy are altered as the kidney ages.

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