What rare genetic disorder is associated with a high incidence of SCC of the esophagus?
- Tylosis is an uncommon autosomal dominant disorder that is distinguished by thickening of the skin (hyperkeratosis) on the palms and soles.
- The syndrome is associated with a 27% incidence of SCC of the esophagus.
- The average age at onset of esophageal cancer is 45 years, and death from esophageal cancer can occur in patients as young as 30 years.
