Clear cell sarcoma is a rare highly malignant tumor of tendons, ligaments, and fascial aponeuroses. It usually presents as a slowly growing mass about the foot.
There are multiple lines of evidence suggesting that clear-cell sarcoma is a representation of malignant melanoma. This evidence includes an immunohistochemical staining pattern with S-100 and HMB-45, which are considered specific for melanoma, evidence of melanin by special staining, and the presence of characteristic premelanosomes by electron microscopy. Treatment consists of surgical excision, radiation, and chemotherapy. Prognosis is generally poor.
