What is glutamate and how is it synthesized and metabolized?
Glutamate is the principal excitatory neurotransmitter of the CNS.
It is formed by transamination of α-ketoglutarate and from glutamine by glutaminase.
Metabolism involves reuptake and recycling by excitatory amino acid transporters (EAAT) expressed on neurons/glia and vesicular glutamate transporters on neurons.
