What conditions cause sequestration into a third space

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What conditions cause sequestration into a third space?

A third space is a space that is not in equilibrium with the ECF space. The following conditions can cause sequestration of fluid into a third space.

• Crush injuries. ECF is sequestered into the damaged skeletal muscle.

• Severe pancreatitis. ECF is sequestered into the inflamed pancreas.

• Intestinal obstruction. ECF is sequestered in the intestinal lumen.

• Skeletal fractures. A large amount of blood may be sequestered in adjacent tissues.

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