What are the various types of kidney transplant rejection as defined by time?
Usually there here are three general types of organ rejection:
- 1. Hyperacute
- 2. Acute
- 3. Chronic
- Hyperacute Rejection is a complement-mediated response by the recipient with preexisting donor specific antibodies (DSA).
- This type of rejection occurs almost immediately following organ implantation.
- This Hyperacute Rejection necessitates immediate explant of the organ.
- Hyperacute rejection is uncommon with pre-transplantation cross-matches and screening.
- Acute rejection is often associated with a sudden deterioration in allograft function
- This type of rejection most commonly happens as early as one week post-transplantation.
- Acute rejection may also be subclinical
- This Acute rejection is associated with a more insidious rise in creatinine.
- Acute rejection has a major adverse effect on long-term graft survival.
- Chronic rejection, better defined as chronic antibody-mediated rejection (AMR), is the main cause of late allograft loss
- This Chronic rejection is defined histologically as transplant glomerulopathy (TG).