Variant forms of Alzheimers disease with an atypical clinical picture
Are there variant forms of Alzheimers (AD) disease that present with an atypical clinical picture?
Yes; these include:
- Posterior cortical atrophy: presents with visuospatial and visual perceptual impairments (e.g., Balint’s syndrome: simultanagnosia, optic ataxia, and ocular apraxia); can also be associated with dementia with Lewy bodies, corticobasal (CB) syndrome, etc., rather than just Alzheimer’s pathology)
- Limbic predominant AD: relatively selective memory impairment; tends to present later that typical AD; many similarities with primary age-related tauopathy (PART; formerly known as tangle predominant dementia )
- Hippocampal-sparing AD: memory spared but with aphasia, apraxia, and/or visual perceptual impairment