Triad of neurologic clinical features with Whipples disease
What is the triad of neurologic clinical features associated with Whipple’s disease?
Whipple’s disease is a multisystem granulomatous infection caused by Tropheryma whippelii .
Neurologic complaints develop in 10% of afflicted patients.
The common triad of findings includes ocular disturbance (often ophthalmoparesis), gait ataxia, and dementia.
Other associated abnormalities include seizures, myelopathy, meningoencephalitis, autonomic dysfunction, and steroid-unresponsive myopathy.
Effective treatment involves antibiotic therapy directed against the organism.
Untreated, most patients die within 1 year of the onset of neurologic symptoms.
