Treatment for XLA CVID and selective IgA deficiency

Treatment for XLA CVID and selective IgA deficiency

IVIG is usually administered in a dose of 200 to 600 mg/kg every month to maintain trough IgG levels of 500 to 800 mg/dL, and then is adjusted for clinical response (less frequent or severe infection). Prophylactic antibiotics is controversial. IVIG should not be administered in patients with IgA deficiency since many patients have autoantibodies against IgA, including IgE anti-IgA, which may result in severe, occasionally fatal anaphylaxis. These patients should ideally receive blood products obtained from other patients with IgA deficiency.

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