Symptoms of child with microcephaly
Is the microcephaly congenital or acquired?
Serial measurements of FOC are helpful. Is the FOC getting progressively worse (Rett’s syndrome in girls), returning to normal (catch-up growth after a serious illness or prematurity), or remaining on the same percentile line (static process)?
Review the antenatal history carefully for evidence of intrauterine infection. Did the infant appear healthy at birth?
Any postnatal central nervous system (CNS) infections or trauma?
Family history of microcephaly?
Hevner R: Brain overgrowth in disorders of RTK-PI3-AKT signaling: a mosaic of malformations. Semin Perinatol 39(1):36-43, 2014.