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Symptoms of autoinflammatory syndromes
characteristic clinical features of autoinflammatory syndromes
- • Acute attacks of fever, elevated inflammatory markers (e.g., erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], white blood cells [WBC]), and symptoms involving joints, internal organs, skin, and eyes.
- • Some syndromes are manifest by nearly continuous symptoms, some by irregular flares, and some by regularly occurring discrete acute attacks that resolve spontaneously.
- • Outside of the most severe/persistent syndromes (i.e., CAPS), patients are usually asymptomatic between episodes, with normal laboratory values.
- • Illnesses and routine vaccinations may provoke flares.