Symptoms of autoinflammatory syndromes

Symptoms of autoinflammatory syndromes

characteristic clinical features of autoinflammatory syndromes

  • • Acute attacks of fever, elevated inflammatory markers (e.g., erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], white blood cells [WBC]), and symptoms involving joints, internal organs, skin, and eyes.
  • • Some syndromes are manifest by nearly continuous symptoms, some by irregular flares, and some by regularly occurring discrete acute attacks that resolve spontaneously.
  • • Outside of the most severe/persistent syndromes (i.e., CAPS), patients are usually asymptomatic between episodes, with normal laboratory values.
  • • Illnesses and routine vaccinations may provoke flares.
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