3 Interesting Facts of Solitary plasmacytoma
- A solitary plasmacytoma is a single tumor composed of monoclonal plasma cells
- A solitary plasmacytoma of bone is a plasma cell tumor located only in bone, without other clinical features (ie, myeloma-defining events) of multiple myeloma
- However, the plasmacytoma itself contains clonal plasma cells that are histologically similar to those that occur in multiple myeloma
- Like multiple myeloma, a solitary plasmacytoma presents with bony pain or with a pathologic fracture of the affected bone
- Most common sites are the vertebrae, pelvis, and ribs
- To define the entity of solitary plasmacytoma, perform additional imaging (with whole body MRI or fludeoxyglucose F 18 PET with CT) and diagnostic testing as follows:
- All 4 criteria must be met to classify a lesion as a solitary plasmacytoma
- Biopsy-proven solitary lesion of bone or soft tissue with evidence of clonal plasma cells
- Normal bone marrow with no evidence of clonal plasma cells
- Normal results on skeletal survey and MRI of spine and pelvis (except for the primary solitary lesion)
- No evidence of end-organ damage such as hypercalcemia, renal insufficiency, anemia, or bone lesions that can be attributed to a lymphoproliferative disorder
- All 4 criteria must be met to classify a lesion as a solitary plasmacytoma
