Small fiber neuropathy

What is small fiber neuropathy? 

Small fiber neuropathy affect the small myelinated A δ and unmyelinated C fibers.

Symptoms usually consist of pain, numbness, burning, “pins and needles-like” sensations, and autonomic disturbances.

On examination, patients may have decreased pinprick and temperature sensation with allodynia and hyperalgesia.

Most patients will have normal sensory nerve conduction studies with a pure small fiber neuropathy and may have an abnormal Quantitative Sensory Testing.

The most common etiologies are diabetes, genetic including amyloidosis, and idiopathic.


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