Serologic abnormalities in IBD

What serologic abnormalities are seen in patients with IBD?

  • • Erythrocyte sedimentation rate (ESR) and C-reactive protein are elevated, whereas rheumatoid factor and antinuclear antibody are negative.
  • • Perinuclear antineutrophil cytoplasmic antibody is seen in more than 55% to 70% of UC patients and fewer than 20% of colon-predominant CD patients. It is usually directed against lactoferrin and less commonly bactericidal permeability increasing protein, cathepsin G, lysozyme, or elastase. It is never directed against myeloperoxidase.
  • • Anti- Saccharomyces cerevisiae is present in 40% to 70% of CD patients and rarely (< 15%) in UC patients.
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