Role of corticosteroids in CIDP

Role of corticosteroids in CIDP

What is the role of corticosteroids in the treatment of CIDP? 

Corticosteroids are an effective treatment for CIDP, and a trial of corticosteroids should be considered in all patients with this condition.

Most patients who respond to prednisone demonstrate a positive effect within 8 weeks of therapy, but high doses (1 mg/kg/day) may be required.

Overall prednisone, prednisolone, or dexamethasone can be used but there is no consensus on whether daily or every other day or intravenous pulse is better. 

Sources

  • Burns TM: Guillain-Barré syndrome. Semin Neurol 28:152-167, 2008. 
  • Hughes RA, et al: Supportive care for patients with Guillain-Barré syndrome. Arch Neurol 62:1194-1198, 2005. 
  • Saperstein DS: Chronic acquired demyelinating polyneuropathies. Semin Neurol 28:168-184, 2008. 
  • Cocito D, et al: Immunosuppressive treatment in refractory chronic inflammatory demyelinating polyradiculoneuropathy. A nationwide retrospective analysis. Eur J Neurol 18:1417-1421, 2011. 
  • Joint task force of the EFNS and PNS: European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy . J Periph Nerv Syst 15:1-9, 2010. 
  • Kleyman I, Brannagan TH: Treatment of chronic inflammatory demyelinating polyneuropathy. Curr Neurol Neurosci Rep 15:47, 2015. 
  • Hughes RA, Mehndiratta MM: Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy. Cochrane Database Syst Rev (1):CD002062, 2015.
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