Risk factors for Complex Regional Pain Syndrome

What are some precipitating factors for the development of CRPS?

Approximately 75% of the time, there is a clear precipitating factor that causes the development of CRPS. It occurs most commonly after fractures (up to 7%), peripheral nerve injury (1%–5%), strokes/myocardial infarctions (5%), sprains, and surgery (especially carpal tunnel surgery). No inciting factor can be identified in 10% to 20% of cases.

Inciting Factors
Trauma (common cause)Chemical burns
Fractures (common cause)Electrical burns
LacerationsPostherpetic neuralgia
Crush injuriesCervical spine pathology
ContusionsSubcutaneous injections
Sprains (common cause)Drugs (barbiturates)
Immobilization in a castMalignancies (ovarian)
Myocardial infarctionsPregnancy
Strokes and other central nervous system (CNS) injury (common cause)Peripheral nerve diseases (common cause)
Pleuropulmonary diseasesEmotional stress
Surgery, especially carpal tunnel syndrome and foot surgery (common cause)
Predisposing Factors
Diabetes mellitusNeurovegetative dystonia
HyperthyroidismAlcohol and/or tobacco abuse
Multiple sclerosisChronic low back pain
Use of angiotensin-converting enzyme (ACE) inhibitors

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