What are some precipitating factors for the development of CRPS?
Approximately 75% of the time, there is a clear precipitating factor that causes the development of CRPS. It occurs most commonly after fractures (up to 7%), peripheral nerve injury (1%–5%), strokes/myocardial infarctions (5%), sprains, and surgery (especially carpal tunnel surgery). No inciting factor can be identified in 10% to 20% of cases.
Trauma (common cause)
Fractures (common cause)
Cervical spine pathology
Sprains (common cause)
Immobilization in a cast
Strokes and other central nervous system (CNS) injury (common cause)
Peripheral nerve diseases (common cause)
Surgery, especially carpal tunnel syndrome and foot surgery (common cause)
Alcohol and/or tobacco abuse
Chronic low back pain
Use of angiotensin-converting enzyme (ACE) inhibitors