Relationship of HLA-B27 positivity in patients with postenteritic reactive arthritis compared with a normal healthy population

Relationship of HLA-B27 positivity in patients with postenteritic reactive arthritis compared with a normal healthy population

  • • Reactive arthritis patients, 60% to 80% HLA-B27 positive; normal healthy controls, 4% to 8% HLA-B27 positive.
  • • Caucasians and patients with radiographic sacroiliitis or uveitis are more likely to be HLA-B27 positive.
  • • A person who is HLA-B27 positive has a 30 to 50 times increased risk of developing reactive arthritis following an episode of infectious gastroenteritis compared with a person who does not have the HLA-B27 gene.
  • • Only 20% to 25% of all HLA-B27 –positive individuals who get an infectious gastroenteritis from Shigella, Salmonella, or Yersinia go on to develop a postenteritic reactive arthritis.
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