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What is pseudohyperphosphatemia?

Elevated phosphorus levels, often mildly elevated (but have been as high as 31 mg/dL), have been encountered in the setting of normal kidney function, calcium, parathyroid hormone, and vitamin D level, suggesting spurious elevation or lab errors: this is pseudohypophosphatemia. It is often a result of a lab assay interference, which can be seen in cases of paraproteinemia, and with the use of liposomal amphotericin B, recombinant tissue plasminogen activator, and heparin sulfate. It is important to be aware of this problem in order to prevent unnecessary and potentially harmful treatments geared at lowering serum phosphorus levels.

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