Preventive analgesia

What is preventive analgesia?

The focus of preventive analgesia is not on the relative timing (preemptive analgesia) of analgesic interventions, but on attenuating the impact of the peripheral nociceptive barrage associated with noxious preoperative, intraoperative, and/or postoperative stimuli. By interrupting the transmission of the peripheral nociceptive barrage to the spinal cord throughout the perioperative period, a preventive approach aims to block the induction of central sensitization, resulting in less intense postoperative pain and lower analgesic requirements. Preventive analgesia is demonstrated when postoperative pain and/or analgesic use are reduced beyond the duration of action of the target drug, and the observed effects are not direct analgesic effects of the target drug.

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