What are the most important peripheral neuropathies associated with autonomic dysfunction?
Peripheral Neuropathies Associated with Autonomic Dysfunction
| Inherited Peripheral Neuropathies with Dysautonomia | ||
| • HSAN I, II, III ∗ (Riley-Day syndrome), IV, and V• HMSN I and II• Fabry’s disease ∗• MEN 2b | • Amyloidosis ∗ (familial amyloid polyneuropathy types I, II, and III)• Porphyria ∗• Some spinocerebellar degenerations | |
| Infectious, Parainfectious, and Immune-Mediated Peripheral Neuropathies with Dysautonomia | ||
| • Leprosy• AIDS• Chagas’ disease• Diphtheria• Systemic lupus erythematosus• Systemic sclerosis• Sjögren syndrome | • Rheumatoid arthritis• Mixed connective tissue disease• GBS ∗• Inflammatory bowel disease• Chronic inflammatory neuropathy• Acute pandysautonomia ∗• Pure cholinergic dysautonomia ∗ | |
| Autonomic Neuropathies Associated with Systemic Metabolic Disease | ||
| • Diabetes ∗• Chronic renal failure• Alcoholism | • Nonalcoholic liver disease• Vitamin B12 deficiency | • Paraneoplastic syndrome• Primary amyloidosis ∗ |
| Autonomic Neuropathies Associated with Industrial Agents, Metals, Toxins, and Drugs | ||
| • Organic solvents• Organophosphates• Acrylamide• Vacor• Heavy metals |
AIDS, acquired immunodeficiency syndrome; GBS, Guillain-Barré syndrome; HMSN, hereditary motor-sensory neuropathy; HSAN, hereditary sensory and autonomic neuropathy; MEN 2bn, multiple endocrine neoplasia type 2b.
∗ Autonomic dysfunction is prominent and clinically important.
