What is orthostatic tremor (OT)?
Orthostatic tremor is a relatively rare but frequently misdiagnosed disorder.
It is more common in women, and the onset is typically in the sixth decade.
It consists of a rapid (13 to 14 Hz) tremor of the legs triggered by standing. Postural tremor of the hands and a family history of Essential Tremor are frequent features, suggesting that OT is a variant of Essential Tremor.
Transcranial magnetic stimulation of the cortex motor area has suggested a supraspinal generator of OT.
Clonazepam is the treatment of choice; other less effective options are propranolol, primidone, gabapentin, and phenobarbital.
