Neuropsychiatric systemic lupus erythematosus (NPSLE)
What are the manifestations of central nervous system (CNS) involvement in SLE or neuropsychiatric systemic lupus erythematosus (NPSLE)?
Autoantibodies Associated with Neuropsychiatric Systemic Lupus Erythematosus
| Antibody | Manifestation |
|---|---|
| Antiphospholipid | Focal neurologic manifestations like transverse myelitis or strokes |
| Antineuronal | Diffuse manifestations |
| Ribosomal P | Psychiatric manifestations, especially psychosis |
| N-methyl-d-aspartate receptor | Cognitive dysfunction (dsDNA cross-react with glutamate receptor) |
| Anti-aquaporin 4/neuromyelitis optica | Transverse myelitis +/– optic neuritis, also see with SSA+ and Sjogren’s syndrome |
