Most sensitive examination for detecting hemochromatosis

Which is the most sensitive examination for detecting hemochromatosis?

MRI: Because many patients with hemochromatosis will develop cirrhosis and 25% will develop HCC, it is important to diagnose early.

US: US examination is normal despite iron deposition, unless underlying cirrhosis is present.

NCCT: Liver attenuation is typically more than 70 HU in hemochromatosis, compared with a normal level of approximately 45 to 60 HU.

MRI: More sensitive and specific than CT in detecting hemochromatosis. On MRI, the paramagnetic effects caused by iron deposition result in decreased T2-w and GRE signal intensity


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