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What is the most common paraneoplastic glomerular disease seen with solid tumors and hematologic malignances?
Membranous nephropathy (MN) remains the most common glomerular pathology reported in patients with solid tumors. The true prevalence of malignancy with MN is unknown.
Minimal change disease (MCD) is the most common glomerular disease associated with hematologic malignancies.
The below table summarizes the published list of paraneoplastic glomerular diseases seen with various types of cancer.
Glomerular Diseases Associated With Solid Tumors and Hematologic Malignancies
| TYPE OF CANCER | ASSOCIATED PARANEOPLASTIC GLOMERULAR DISEASE |
|---|---|
| Lung cancer (includes small cell, non-small-cell, squamous cell, and bronchogenic cancers) | MN, MCD, MPGN, IgAN, FSGS, CGN, HSP, TMA |
| Renal cell cancer | AAA, CGN, IgAN, MCD, FSGS, MPGN, HSP |
| Colon cancer | MN, MCD, CGN |
| Gastric cancer | MN, MPGN, CGN, HSP, TMA |
| Prostate cancer | MN, CGN, HSP |
| Pancreatic cancer | MN, MCD, IgAN |
| Breast cancer | MN, FSGS, MPGN, HSP, TMA |
| Esophageal cancer | MPGN, FSGS |
| Head and neck cancer | MN, IgAN |
| Ovarian cancer | MN, MCD |
| Cervical cancer | MN |
| Endometrial cancer | MN |
| Melanoma | MN, MPGN, MN |
| Hodgkin’s lymphoma | MCD, MN, MPGN, IgAN, FSGS, CGN, AAA, Anti-GBM disease, HSP |
| Non-Hodgkin’s lymphoma | MN, MCD, MPGN, IgAN, FSGS, HSP |
| Chronic lymphocytic leukemia | MPGN, MN, MCD, FSGS, CGN |
| Acute myelogenous leukemia | MN, FSGS |
| Chronic myelogenous leukemia | FSGS, MN, MCD, MPGN |
| MGUS | MPGN, TMA, C3GN |
| T-cell leukemia | FSGS |
AAA , AA amyloidosis; C3GN , complete C3 glomerulonephritis; CGN , crescentic glomerulonephritis; FSGS , focal segmental glomerulosclerosis; GBM , glomerular basement membrane; HSP , Henoch–Schonlein purpura, IgAN , immunoglobulin A nephropathy; MCD , minimal change disease; MGUS , monoclonal gammopathy of unclear significance; MN , membranous nephropathy; MPGN , membranoproliferative glomerulonephritis; TMA , thrombotic microangiopathy.Modified from Jhaveri, K. D., Shah, H. H., Calderon, K., Campenot, E. S., & Radhakrishnan, J. (2013). Glomerular diseases seen with cancer and chemotherapy: A narrative review. Kidney International, 84 (1), 34–44.
