Mononeuritis multiplex

What is mononeuritis multiplex?

Mononeuritis multiplex is a pattern of motor and sensory involvement of multiple individual peripheral nerves that is a classic neurologic presentation of systemic vasculitis. First, one peripheral nerve becomes involved (usually with burning dysesthesias), followed by other individual nerves, often with motor dysfunction as well. The patchy nature of nerve involvement reflects the patchy vasculitis of the vasa nervorum, which is the underlying cause of the neuropathy. Mononeuritis multiplex can also be present in diabetes mellitus, sarcoidosis, lead neuropathy, and Wartenberg’s migratory sensory neuritis.

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