What is monoclonal gammopathy of renal significance (MGRS)?
Monoclonal gammopathy of renal significance is now used to define a group of B cell lymphoproliferative disorders and plasma cell disorders that do not meet criteria for myeloma, WM, or lymphoma/leukemia, yet lead to a histologically defined pattern of kidney injury directly attributable to the paraprotein or LC.
In MGRS, the clonal expansion is often low and below any diagnostic threshold for malignancy yet the paraprotein or the LC component is associated with clinical disease of a heterogeneous and significant nature (e.g., amyloidosis, MIDD). Because they have not been previously considered a malignant disorder, this has restricted their access to therapy required for control of the clonal disorder and caused confusion with diagnosis and management.
Separating them into a separate group allows better clinical management options and research focus.
