Malignancy Associated Rheumatic Disorders
1. The increased risk of lymphoma in rheumatoid arthritis, systemic lupus erythematosus, and Sjögren’s syndrome is largely driven by the disease activity of the rheumatic disease.
2. The presence of selected antibodies (transcription intermediary factor [TIF]-1 gamma or nuclear matrix protein [NXP]-2) in dermatomyositis (DM)/polymyositis (PM) and autoantibodies (to RNA polymerase III or anti-RNPC-3) in systemic sclerosis reflect a significantly increased risk of concurrent malignancy.
3. When palmar fasciitis presents in a woman, consider ovarian carcinoma.
4. Lymphoma and common solid tumors may be associated with connective tissue disease (CTD).
5. Leukocytoclastic vasculitis is the most common paraneoplastic vasculitis presentation.
6. Cancer therapies including immune checkpoint inhibitors can cause a variety of rheumatic syndromes.
