What's on this Page
Major Causes of Osteomalacia
Osteomalacia, which means “soft bones,” results from impaired mineralization of bone matrix due to inadequate concentrations of serum phosphate and/or calcium, resulting in a low serum calcium x phosphate product, or from a circulating inhibitor of mineralization.
Major Causes of Osteomalacia
- Vitamin D deficiency
- Low oral intake plus inadequate sunlight exposure
- Intestinal malabsorption
- Abnormal vitamin D metabolism
- Liver disease
- Renal disease
- Drugs (anticonvulsants, antituberculosis drugs, ketoconazole)
- Hypophosphatemia
- Low oral phosphate intake
- Phosphate-binding antacids
- Excess renal phosphate loss
- Inhibitors of mineralization
- Aluminum
- Bisphosphonates
- Fluoride
- Hypophosphatasia
