Major Causes of Osteomalacia

Major Causes of Osteomalacia

Osteomalacia, which means “soft bones,” results from impaired mineralization of bone matrix due to inadequate concentrations of serum phosphate and/or calcium, resulting in a low serum calcium x phosphate product, or from a circulating inhibitor of mineralization.

Major Causes of Osteomalacia

  • Vitamin D deficiency
    • Low oral intake plus inadequate sunlight exposure
    • Intestinal malabsorption
    • Abnormal vitamin D metabolism
    • Liver disease
    • Renal disease
    • Drugs (anticonvulsants, antituberculosis drugs, ketoconazole)
  • Hypophosphatemia
    • Low oral phosphate intake
    • Phosphate-binding antacids
    • Excess renal phosphate loss
  • Inhibitors of mineralization
    • Aluminum
    • Bisphosphonates
    • Fluoride
  • Hypophosphatasia
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