Main clinical features of progressive supranuclear palsy

Main clinical features of progressive supranuclear palsy

What are the main clinical features of progressive supranuclear palsy (PSP)? 

Progressive supranuclear palsy is the second most common cause of idiopathic parkinsonism.

Typically, the onset is in the seventh decade, with no family history.

Patients have ophthalmoparesis of downgaze, parkinsonism, pseudobulbar palsy, and frontal lobe signs.

Eyelid abnormalities are common.

For example, patients with eyelid freezing have difficulty with either opening or closing the eyes due to inhibition of levator palpebrae or orbicularis oculi muscles, respectively.

The prevalence of dystonia in patients with pathologically proven progressive supranuclear palsy is about 13%.

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