In which diseases antibodies against cytoplasmic antigens can be more helpful diagnostically than antibodies against nuclear antigens

In which diseases antibodies against cytoplasmic antigens can be more helpful diagnostically than antibodies against nuclear antigens?

Patients with these diseases frequently lack antibodies to nuclear antigens and are, therefore, often ANA-negative.

Consequently, the specific anticytoplasmic antibody should be ordered when these diseases are suspected. 

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