What is the spectrum of immune related adverse events seen with ICPIs?
Immune-related adverse events (IRAEs) affect multiple organs and systems, including the skin, gastrointestinal (GI) tract, heart, lungs, kidneys, eyes, musculoskeletal system, nervous system, hematologic system and the endocrine system.
|Pruritis, Rash||3–4 weeks||7–8 weeks|
|Colitis, Diarrhea||4–6 weeks||5–6 weeks|
|Hepatic Toxicity||6–8 weeks||7–8 weeks|
|Hypophysitis||6–8 weeks||Permanent (usually)|