Immune related side effects of ICPIs

What is the spectrum of immune related adverse events seen with ICPIs?

Immune-related adverse events (IRAEs) affect multiple organs and systems, including the skin, gastrointestinal (GI) tract, heart, lungs, kidneys, eyes, musculoskeletal system, nervous system, hematologic system and the endocrine system.

Pruritis, Rash3–4 weeks7–8 weeks
Colitis, Diarrhea4–6 weeks5–6 weeks
Hepatic Toxicity6–8 weeks7–8 weeks
Hypophysitis6–8 weeksPermanent (usually)

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