How is Multiple system atrophy treated?
Dopaminergic drugs are the mainstay of the treatment of Multiple system atrophy.
However, despite the use of high doses of levodopa, no significant improvement is usually observed.
The loss of cells in the striatum and widespread lesions of other neurotransmitters probably accounts for the failure of treatment.
The use of midodrine, fludrocortisone, droxidopa, and pyridostigmine may assist in the symptomatic management and control of orthostatic hypotension from autonomic dysfunction.