What is meant by fatigability? How is fatigability useful in diagnosing neuromuscular disease?
Fatigability is defined as progressive weakness of muscle with repetitive use, followed by recovery of strength after a brief period of rest. It is a classic finding in myasthenia gravis often involving eye movements, eyelids (ptosis), and proximal upper extremity muscle groups. Lambert–Eaton myasthenic syndrome is often the reverse of myasthenia gravis, where there is a paradoxical increase in the muscle strength observed with repetitive muscle contraction.