How is a patient with a positive FOBT evaluated

How is a patient with a positive fecal occult blood test (FOBT) evaluated? 

The evaluation of a positive FOBT depends somewhat on the clinical situation. 

Asymptomatic persons with positive FOBT and iron-deficient anemia require colonoscopy. If colonoscopy is negative for a source of FOBT or anemia, then esophagogastroduodenoscopy (EGD) should be performed.

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