How does Pagets Disease of Bone contribute to Osteoarthritis risk?
OA is common in PDB and is present in 40% to 50% of patients. PDB commonly affects bone adjacent to joints and can contribute to OA by causing bony incongruencies. Bowing of long bones can increase the risk of OA as it alters gait and increases stress on joints via altered force transmission through the joint and premature loss of articular cartilage. Pagetic pain may cause people to favor their nonpagetic leg, which can contribute to OA development on the unaffected side.
