Complications of Pagets Disease of Bone

Complications of Pagets Disease of Bone

What complications can arise in Pagets Disease of Bone?

  • Skeletal
    • Bone pain
    • Bone and joint deformities (bowing, frontal bossing)
    • Fractures (7% of patients)
  • Neurologic
    • Deafness (auditory nerve entrapment or involvement of bones of inner ear; 13%)
    • Nerve entrapment (cranial nerves, spinal nerve roots)
    • Spinal stenosis
    • Basilar invagination
    • Headaches, vertigo, tinnitus
    • Stroke (blood vessel compression)
  • Vascular
    • Hyperthermia
    • Vascular steal syndrome (external carotid blood flow to the skull at the expense of the brain)
  • Cardiac
    • High-output congestive heart failure (due to increased pagetic bone vascularity when over 40% of skeleton involved)
    • Hypertension
    • Cardiomegaly
    • Angina
  • Malignancy
    • Osteogenic sarcomas (most commonly in humerus; 1%)
    • Fibrosarcomas, chondrosarcomas
    • Benign giant cell tumors
  • Metabolic
    • Hypercalcemia
    • Hypercalcuria
    • Nephrocalcinosis
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856