How do antidepressants which inhibit norepinephrine and serotonin reuptake reduce pain

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How do antidepressants which inhibit norepinephrine and serotonin reuptake reduce pain? 

These drugs work on the descending inhibitory pathways.

They increase K influx and block Ca ++ influx at the second-order neuron in the dorsal horn.

It should be noted, however, that this mechanism of action depends on the type of 5-HT receptor since some subtypes are excitatory rather than inhibitory.

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