How common is Sepsis associated acute kidney injury
What are the key epidemiologic aspects of acute kidney injury in the setting of sepsis?
Sepsis is common among intensive care unit (ICU) patients with a prevalence ranging from 8.2% to 35.3% of all ICU patients.
Sepsis is becoming more common.
A recent large study in the United States showed an increase of 8.7% of sepsis as the primary diagnosis from the previous year.
However, the overall sepsis-associated mortality rate appears to be decreasing (between 18% and 25%).
Sepsis is associated with significant deleterious effects on outcomes:
- • Extended mechanical ventilation
- • Prolonged hospitalization
- • Secondary infections
- • Increased long-term mortality
Although the etiology of acute kidney injury in patients who are critically ill is often multifactorial, sepsis has consistently been found to be an important, if not the most important, contributing factor.
Several studies have shown that approximately 40% to 50% of patients with acute kidney injury on presentation to an ICU have concomitant sepsis and that up to 64% of patients who are critically ill with a diagnosis of severe sepsis or septic shock have concomitant acute kidney injury.
