How are organ specific toxicities caused by immunotherapies graded

How are organ specific toxicities caused by immunotherapies graded?

The National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) is a descriptive terminology used for adverse event (AE) reporting. A grade refers to the severity of an AE and a general guideline is used to grade AEs on a scale of 1 through 5. Grade 1 AEs are defined as mild or no symptoms and can be clinically monitored without intervention. Grade 2 AEs are moderate and limit age-appropriate activities of daily living (ADLs); minimal, local, or noninvasive intervention is indicated. Grade 3 AEs are severe, but not immediately life-threatening; they limit self-care ADLs, and hospitalization is generally needed. Grade 4 AEs have life-threatening consequences, and urgent intervention is needed. A Grade 5 AE is one that leads to a patient’s death.


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