Giant prolactinoma

What is a giant prolactinoma?

Giant prolactinomas are defined as prolactinomas > 4 cm in size. Cabergoline is usually the initial treatment of choice, although high doses may be required; surgery is indicated for cabergoline-resistant cases, and radiation therapy can be added if the tumor progresses. If progression continues despite these measures, temozolomide, an alkylating agent that depletes a DNA repair enzyme, can be considered.


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