Factors associated with poor prognosis of Membranous Nephropathy

Factors associated with poor prognosis of Membranous Nephropathy

Several factors are associated with worse outcome in patients with MN including:

• Advanced age (>50)

• Male sex

• Elevated blood pressure

• CKD (low estimated glomerular filtration rat at presentation)

• Severity of initial proteinuria

• Persistent proteinuria

Persistent proteinuria of >4 g/24 hours is the strongest predictor of progressive kidney disease.

Histologic changes such as tubular atrophy, interstitial fibrosis, and glomerulosclerosis have also been associated with poor prognosis.

Elevated β 2 -microglobulin urinary excretion rate has been shown to predict poor outcome, but accurate measurement of urinary β 2 -microglobulin can be challenging.

Increasing evidence suggests that high anti-PLA 2 R autoantibody levels may be used in diagnosis and management of MN and to predict long-term outcomes.

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