Emerging novel analgesics in the pipeline for chronic pain

What are some of the emerging novel analgesics in the pipeline for chronic pain?

There are a number of pharmacological agents with novel mechanisms in both preclinical and clinical development.

These agents target mechanisms that modulate pain at various levels of the nervous system. 

Here is the table which lists the most promising emerging analgesics.

Emerging Novel Analgesics for Chronic Pain

NGF Inhibitors PAP T-type Calcium Channel Blockers N-type Calcium Channel Blockers Angiotensin II type 2 Receptor Antagonists Selective Sodium Channel Blockers TRPV1 Channel Antagonists AMPA/Kainate Antagonists Cannabinoids p38 Kinase Inhibitors CCR2 Antagonists KCNQ Agonists P2X Purinoreceptor Antagonists

NGF, Nerve growth factor; PAP, prostatic acid phosphatase; TRPV1, transient receptor potential cation channels, subfamily